(Translated with MistralAI without further editing)

The focus of TT49 is on science-based deep-tech startups emerging from German research. How do you currently assess the potential of chemistry startups originating from universities or Fraunhofer Institutes, and which specific technologies do you see as particularly promising?

We currently see enormous potential in science-based chemistry and materials startups. Germany, in particular, has an internationally strong research landscape with excellent basic research and high industrial relevance. We find technologies in sustainable materials, battery materials, circular economy, CO₂ utilization, green chemistry, and AI-driven process optimization especially exciting. Many of these technologies simultaneously address challenges related to decarbonization and European industrial sovereignty.

Many (chemistry) startups fail in the “Valley of Death” between research and market readiness. How does TT49 specifically support startups in the pre-seed phase?

TT49 positions itself precisely in this early phase. We typically invest immediately after a startup is spun out of research. Our focus is on providing capital as well as addressing framework conditions and questions related to IP structures, market validation, team composition, industry access, and preparation for further funding rounds. Public funding programs play a central role, especially for capital-intensive technologies. Our goal is to translate scientific excellence into entrepreneurial success at an early stage.

The chemical industry faces enormous challenges due to new and existing EU regulations. How do you help startups overcome these regulatory hurdles?

Regulatory requirements are an integral part of business strategy in deep tech and chemistry from the very beginning. Accordingly, regulatory expertise and early engagement with industry partners, authorities, and specialized consultants gain importance. Sustainability is generally seen more as a driver than a risk. Many startups emerge because existing industrial processes are increasingly reaching their limits, whether in terms of energy efficiency, CO₂ reduction, or circular economy.

How do you leverage your own network to support startups not only financially but also by providing access to pilot customers, industry partners, or infrastructure?

Our network is one of the most important value-adds of TT49. Through our proximity to research institutions, industrial companies, family offices, and other VC investors, we can connect young companies with relevant partners at a very early stage. In the chemistry and deep-tech sectors, pilot projects, access to lab and production infrastructure, and industrial validation are critical for success. Here, we actively work to open doors and enable long-term strategic partnerships.

Is there anything else you would like to share with our readers?

Germany has an exceptionally strong research landscape. The key now is to translate more scientific excellence into market-ready companies more quickly. This requires entrepreneurial courage, long-term capital, and close collaboration between science, industry, and investors.

About Johann C. Siemes

Johann C. Siemes is Managing Partner at TT49 Management GmbH, the successor fund to the Fraunhofer Technology Transfer Fund (FTTF). He supports science-based deep-tech startups from German research institutions and universities in early financing phases, helping teams build scalable business models, strategic partnerships, and secure follow-on funding. TT49 particularly focuses on technology-driven spin-offs with high industrial impact.